Academic Interests

My research program is focused on defining the pathologic mechanisms which lead from injury to fibrosis in the lung. In particular, I am interested in defining the role of endothelial dysfunction and vascular permeability in the development of pulmonary fibrosis. I have projects looking at the role of endothelial signaling pathways regulated by Rho kinase (ROCK) and Sphingosine-1-phosphate (S1P) in the development of both idiopathic pulmonary fibrosis (IPF) and post-viral pulmonary fibrosis. I am also interested in the development of molecular imaging tools to identify active fibrogenesis using pre-clinical models, with the goal of building novel tools to identify active disease in patients to guide treatment choices by clinicians.